Flow Chemistry

In Flow Chemistry, two or more reagents are continuously pumped into a flow reactor, where they mix and subsequently react under thermal control. The major advantages of Flow Chemistry are:

- faster reactions

Mixing can be achieved within seconds and reaction temperature can be raised above the solvent's boiling point.

- cleaner products

Flow Chemistry enables excellent reaction selectivity. Rapid diffusion based mixing avoids the issues found in batch reactors. High surface area to volume ratios (1000x greater than a batch reactor) enable almost instantaneous heating or cooling, giving ultimate temperature control. The high surface area also allows excellent control of exothermic reactions using Flow Chemistry.

- safer reactions

Flow Chemistry allows only a small amount of hazardous intermediate to be formed at any time.

- fast reaction optimization

Flow Chemistry with automation enables the rapid variation of reaction conditions on a µl-scale. Parameters such as reaction time, temperature, flow rate/volume and pressure can all be varied quickly. One reaction can follow another, by flushing the reactor with solvent.

- easy scale-up

Scale-up issues are minimized with Flow Chemistry by maintaining excellent mixing and heat transfer. Higher flow rates and larger reactors can be used to produce kilogram/tonne quantities using Flow Chemistry.