Chemtrix contributes to the international consortium of CCFLOW

August 8 2017, Geleen

which is working towards delivering a more cost-effective manufacturing approach for API’s


In July 2017, together with twelve industrial, three scientific and two associated partners, Chemtrix became part of the ‘K-Project’ CCFLOW – “Center for Continous Flow Synthesis and Processing” which is supported and sponsored by the Austrian Research Promotion Agency (FFG). The Center’s Scientific Director is Prof. Oliver Kappe, who has been researching in this field at University of Graz for more than 15 years.  


This challenging project will be executed by scientific partners the Research Center Pharmaceutical Engineering (RCPE),  University of Graz (UG), and Graz University of Technology (TUG) and be supported by Industrial Partners. The K-project has received an initial four-year funding phase and will run from July 2017 to June 2021 with a project volume of 4.7 million €.   


The strategic objective of this new K-project is to integrate, strengthen and to advance existing knowledge in the areas of continuous processing and flow chemistry to enable the development of novel, innovative and scalable methods for the continuous production of Active Pharmaceutical Ingredients (APIs). The approach heavily relies on the three principles of process simplification, process intensification and process integration. 


In parallel there will be focus on developing a deep fundamental scientific understanding of all the key parameters along the process chain from synthetic chemistry and reaction engineering, to reactor and plant design.


To achieve this goal, a particular and diverse skill set is needed that includes synthetic chemistry, chemical engineering, process analytics, plant and process engineering, simulation science, additive manufacturing and separation sciences.  This is achieved via the creation of an academic-industrial consortium;


CCFLOW Scientific Partners:  Research Center Pharmaceutical Engineering, Graz University of Technology and University of Graz.


CCFLOW Project Partners[c1]:  Anton Parr, AstraZeneca, Chemtrix, Eli Lilly, E. L. T., Lithoz, Lonza, Microinnova, Patheon, Phyllon, Prozess Optimal, Thales Nano and UCB.


CCFLOW Associated Partners:  Janssen Pharmaceutica and Zaiput Flow Technologies.