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DSM AND CHEMTRIX SIGN COLLABORATION AGREEMENT IN CONTINUOUS FLOW CHEMISTRY
 | DSM Pharmaceutical Products, the custom manufacturing and technology business of Royal DSM (NYSE, Euronext: DSM KON), announced today that it has signed a collaboration agreement with Chemtrix B.V., The Netherlands, in the field of Continuous Flow Chemistry to provide sustainable equipment and, development and manufacturing services to the pharmaceutical industry.
The agreement brings together the expertise of both parties in continuous flow chemistry to better serve the pharmaceutical industry with processes for the development and manufacture of active pharmaceutical ingredients (APIs), which require new technologies to increase sustainability, reduce... |
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Hasselt University demonstrates continuous flow derivatisation of RAFT-polymers
J. Vandenbergh and T. Junkers
Performing initial condition screening within a Labtrix® micro reactor, Junkers and Vandenberg of the Universiteit Hasselt (Belgium), demonstrated the ability to utilise this emerging technology for the highly controlled thiol-ene derivatisation of poly(n-butyl acrylate) affording a nine-fold reduction in reaction times compared to batch. This efficient derivatisation of RAFT-polymers, affords comparable products to those generated in batch – opening up the...
J. Vandenbergh and T. Junkers
Performing initial condition screening within a Labtrix® micro reactor, Junkers and Vandenberg of the Universiteit Hasselt (Belgium), demonstrated the ability to utilise this emerging technology for the highly controlled thiol-ene derivatisation of poly(n-butyl acrylate) affording a nine-fold reduction in reaction times compared to batch. This efficient derivatisation of RAFT-polymers, affords comparable products to those generated in batch – opening up the...Ghent University demonstrates efficient and direct scale-up from method development to production
F. E. A. Van Waes, J. Drabowicz, A. Cukalovic and C. V. Stevens
Employing the scalable flow chemistry platform from Chemtrix BV, researchers at Ghent University report an efficient, catalyst-free method for the synthesis of esters at throughputs in excess of 132 g/h. Employing Labtrix® Start, mg-quantities of reagents were consumed for the optimization of reaction parameters, the results of which were directly transferred to KiloFlow®, where up to a 1380x scale-up was accessed in a standard laboratory fume cupboard....
F. E. A. Van Waes, J. Drabowicz, A. Cukalovic and C. V. Stevens
Employing the scalable flow chemistry platform from Chemtrix BV, researchers at Ghent University report an efficient, catalyst-free method for the synthesis of esters at throughputs in excess of 132 g/h. Employing Labtrix® Start, mg-quantities of reagents were consumed for the optimization of reaction parameters, the results of which were directly transferred to KiloFlow®, where up to a 1380x scale-up was accessed in a standard laboratory fume cupboard....Application Note: Direct Scale-up from mg to 1 kg, in one Week!
Dr. Charlotte Wiles, 2013-01-29
Using the scalable flow chemistry platform from Chemtrix BV, turn-key systems containing glass reactors were used for the optimization and execution of synthetic reactions. Employing Labtrix®-S1, mg-quantities of reagents were consumed for the automated assessment of reaction parameters , the results of which can be directly transferred to KiloFlow®, where up to a 13,000x scale-up can be accessed in a standard laboratory fume cupboard. To demonstrate the...
Dr. Charlotte Wiles, 2013-01-29
Using the scalable flow chemistry platform from Chemtrix BV, turn-key systems containing glass reactors were used for the optimization and execution of synthetic reactions. Employing Labtrix®-S1, mg-quantities of reagents were consumed for the automated assessment of reaction parameters , the results of which can be directly transferred to KiloFlow®, where up to a 13,000x scale-up can be accessed in a standard laboratory fume cupboard. To demonstrate the...Design of Experiment (DoE) in Continuous Flow
Dr. C. Wiles, 2012-12-05
Using Labtrix® S1, researchers at Sanofi (Budapest) and Budapest University of Technology & Economics assess the optimisation of reactions utilising the "the safety concerned reagent" hydroxylamine. Employing DoE (Design of Experiments), the authors readily indentified the optimal workspace for the synthesis of thirteen benzamidoximes; precursors in the preparation of biologically relevant oxadiazoles, and demonstrated the ability to scale (x450)...
Dr. C. Wiles, 2012-12-05
Using Labtrix® S1, researchers at Sanofi (Budapest) and Budapest University of Technology & Economics assess the optimisation of reactions utilising the "the safety concerned reagent" hydroxylamine. Employing DoE (Design of Experiments), the authors readily indentified the optimal workspace for the synthesis of thirteen benzamidoximes; precursors in the preparation of biologically relevant oxadiazoles, and demonstrated the ability to scale (x450)...EVENTS
Fifth Symposium on Continuous Flow Reactor Technology for Industrial Applications
September 11 - 12, Pisa, Italy
September 11 - 12, Pisa, Italy
2nd SCI/RSC Symposium on Continuous Processing and Flow Chemistry
September 24 - 25, Novartis Horsham, United Kingdom
September 24 - 25, Novartis Horsham, United Kingdom
